The Ozaki Laboratory of the Division of Vascular and Endovascular Surgery Basic Vascular Biology Lab broadly aims to delineate the mechanisms by which physical forces alter the morphology of the blood vessel wall. The team holds expertise specifically in the adaptations of the vein bypass graft, an extreme example of acute perturbation of the hemodynamic environment combined with vascular trauma. Recent investigative efforts have focused on inflammatory driven mechanisms of these adaptations. Future research directions will expand (in both animal models and humans) this foundation of knowledge via enhanced in vivo imaging of the blood vessel wall, and robust analyses of the longitudinal interplay between local hemodynamic factors and biologic mediators.

Staff